Author

M. A. Munoz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Cancer Biology· 1 Evolutionary Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

E. K. Fletcher· 2 shared E. Kristianto· 2 shared J. Jurczyluk· 2 shared M. J. Rogers· 2 shared M. Sireci· 2 shared O. P. Skinner· 2 shared A. A. Robertson· 1 shared A. Simon· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersPhysiology

E. K. Fletcher

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Statistical mechanics of phenotypic eco-evolution: from adaptive dynamics to complex diversification

M. Sireci, M. A. Munoz

This paper develops a statistical mechanics framework to derive macroscopic evolutionary equations from microscopic stochastic dynamics, showing dynamical phase transitions in phenotypic space.

bioRxiv · Jul 20, 2023Evolutionary Biology

Environmental fluctuations explain the universal decay of species-abundance correlations with phylogenetic distance

M. Sireci, M. A. Munoz, J. A. Grilli

The paper identifies a macroecological law showing species-abundance correlations decay with phylogenetic distance, attributing this to environmental filtering rather than competition.

bioRxiv · Jul 12, 2022Ecology

Genetic Screen in a Pre-Clinical Model of High-Grade Complex Karyotype Sarcoma Characterizes Drivers of Distinct Sarcoma Subtypes and Identifies New Therapeutic Vulnerabilities

M. A. Munoz, J. Freeland, E. O'Donnell, J. Langerman, J. Bergonio, J. Surarez-Navarro, M. Darrow, S. Thorpe, R. Randall, K. L. Carraway, O. Witte, T. Graeber, J. Carr-Ascher

This paper develops a pre-clinical model of high-grade complex karyotype sarcomas to identify subtype-specific drivers and therapeutic targets through genetic screening and transcriptomic analysis.

bioRxiv · Jun 13, 2022 · PreprintCancer Biology

Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency

M. A. Munoz, O. P. Skinner, E. Masle-Farquhar, J. Jurczyluk, Y. Xiao, E. K. Fletcher, E. Kristianto, M. P. Hodson, S. I. O'Donoghue, S. Kaur, R. Brink, D. Zahra, E. K. Deenick, K. Perry, A. A. Robertson, , M. J. Rogers

This study shows that increased body temperature worsens protein prenylation defects in mouse models of mevalonate kinase deficiency, suggesting temperature as a trigger for inflammation.

bioRxiv · Feb 28, 2022 · PreprintPhysiology

Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages

M. J. Rogers, M. A. Munoz, E. K. Fletcher, O. P. Skinner, J. Jurczyluk, E. Kristianto, M. Hodson, S. Sun, F. H. Ebetino, D. R. Croucher, P. M. Hansbro, J. R. Center

This study shows bisphosphonates inhibit the mevalonate pathway in macrophages, enhancing immune responses to bacterial endotoxin in the lung.

bioRxiv · Aug 9, 2021Pharmacology & Toxicology

Bet-hedging strategies in expanding populations

P. Villa Martin, M. A. Munoz, S. Pigolotti

This paper develops a theory of bet-hedging for expanding populations in fluctuating environments, finding it more advantageous in spatially fluctuating environments and at slow variation rates.

bioRxiv · Sep 27, 2018Ecology

Diversity Of Biocrust-Forming Cyanobacteria In A Semiarid Gypsiferous Site From Central Spain

C. Cano-Diaz, P. Mateo, M. A. Munoz, F. T. Maestre

The paper studies cyanobacteria diversity in a semiarid gypsiferous site in Central Spain using morphological and genetic methods, identifying new genera and phylotypes.

bioRxiv · May 10, 2017Microbiology