Y. Tu

Programmable Editing of Primary MicroRNA Switches Stem Cell Differentiation and Improves Tissue Regeneration

The paper introduces REPRESS, a tool for editing pri-miRNA to suppress miRNA, and demonstrates its application in stem cell differentiation and tissue regeneration.

Bacterial motility depends on a critical flagellum length and energy-optimised assembly

This study shows that bacterial flagellum assembly is optimized for energy efficiency and motility by balancing secretion rate and filament length.

Identification of a Conserved B-Cell Epitope on the Capsid Protein of Porcine Circovirus Type 4

This study identifies a conserved B-cell epitope on the PCV4 capsid protein, which could aid in vaccine and detection strategies for PCV4.

The stability of lower genital tract microbiota correlates with reproductive system function and in vitro fertilization and frozen embryo transfer outcomes in women with polycystic ovarian syndrome

This study investigates the relationship between lower genital tract microbiota and reproductive outcomes in PCOS patients, finding that higher Lactobacillus abundance correlates with better IVF-FET outcomes.

Single-cell Sequencing Highlights Heterogeneity and Malignant Progression in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

This study uses single-cell RNA-seq to analyze the progression from actinic keratosis to cutaneous squamous cell carcinoma, identifying key driver genes and tumor microenvironment interactions.

Tunable photoinitiated hydrogel microspheres for direct quantification of cell-generated forces in complex three-dimensional environments

This paper develops tunable hydrogel microspheres for quantifying cell-generated forces in 3D environments using microfluidics and photopolymerization.

Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

A cooperative switch within the KaiC hexamer revealed by cryo-EM

The paper uses cryo-EM to reveal cooperative conformational changes in KaiC hexamers that enable switch-like phosphorylation responses.

A multi-state dynamic process confers mechano-adaptation to the bacterial flagellar motor

The paper studies mechano-adaptation in bacterial flagellar motors by analyzing stator unit binding dynamics and proposes a minimal model explaining the observed behavior.

Dynamic Instability of Dendrite Tips Generates the Highly Branched Morphologies of Sensory Neurons

This study shows that dynamic instability at dendrite tips generates complex branching in Drosophila sensory neurons through stochastic transitions between growth, shrinkage, and pause states.

Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation

The paper shows that the mechanosensitive remodeling of the bacterial flagellar motor depends on torque, not rotation direction, and presents a mathematical model to explain this behavior.

Filtering input fluctuations in intensity and in time underlies transcriptional pulses without feedback

The paper identifies a filter-and-integrate mechanism in E. coli that generates stochastic transcriptional pulses without feedback by eliminating FlhDC fluctuations.

Error-speed correlations in biopolymer synthesis

This study shows that error and speed in biopolymer synthesis are correlated, with enzyme error-correction mechanisms determining whether faster synthesis leads to better or worse errors.

Activity of Antimicrobial Peptides Decreases with Increased Cell Membrane Crossing Free Energy Cost

This study shows that increased intermolecular interactions in antimicrobial peptides raise the energy cost to cross bacterial membranes, reducing their antibacterial activity.