Author

S. Preissler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

D. Ron· 3 shared L. A. Perera· 3 shared C. Rato· 2 shared Y. Yan· 2 shared A. Czako· 1 shared J. M. Devos· 1 shared L. Neidhardt· 1 shared M. Haertlein· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

D. Ron

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3 papers

Recent·Most cited

Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

L. A. Perera, S. Preissler, N. R. Zaccai, S. Prevost, J. M. Devos, M. Haertlein, D. Ron

This paper presents crystallographic and solution structures of the FICD-BiP deAMPylation complex, revealing how FICD switches between AMPylation and deAMPylation activities through conformational changes.

bioRxiv · Apr 20, 2021Biochemistry

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

S. Preissler, C. Rato, Y. Yan, L. A. Perera, A. Czako, D. Ron

This study shows that calcium depletion affects BiP-substrate interactions by altering ADP affinity, impacting ER proteostasis and UPR activation.

bioRxiv · Nov 3, 2020Biochemistry

An oligomeric state-dependent switch in FICD regulates AMPylation and deAMPylation of the chaperone BiP

L. A. Perera, C. Rato, Y. Yan, L. Neidhardt, S. H. McLaughlin, R. J. Read, S. Preissler, D. Ron

This paper identifies how FICD switches between AMPylation and deAMPylation of BiP by changing its oligomeric state, regulated by ATP/ADP levels.

bioRxiv · Apr 1, 2019Biochemistry