Author

C. Rato

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:biophysical modeling· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:ecology & biodiversity· 1 Organism:human· 1

Frequent Co-Authors

D. Ron· 3 shared L. A. Perera· 2 shared S. Preissler· 2 shared Y. Yan· 2 shared A. Crespillo-Casado· 1 shared A. Czako· 1 shared A. Sakamoto· 1 shared A. Zyryanova· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

D. Ron

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Author profile →

4 papers

Recent·Most cited

Uncovered genetic diversity in Hemidactylus mabouia (Reptilia: Gekkonidae) from Madeira Island reveals uncertain sources of introduction

C. Rato, B. Martins, R. Rocha, I. Silva-Rocha

The study identifies two distinct genetic lineages of Hemidactylus mabouia in Madeira Island, challenging previous assumptions about its introduction source.

bioRxiv · Mar 2, 2021Evolutionary Biology

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

S. Preissler, C. Rato, Y. Yan, L. A. Perera, A. Czako, D. Ron

This study shows that calcium depletion affects BiP-substrate interactions by altering ADP affinity, impacting ER proteostasis and UPR activation.

bioRxiv · Nov 3, 2020Biochemistry

ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

A. Zyryanova, K. Kashiwagi, C. Rato, H. P. Harding, A. Crespillo-Casado, L. Perera, A. Sakamoto, M. Nishimoto, M. Yonemochi, M. Shirouzu, T. Ito, D. Ron

This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.

bioRxiv · Sep 28, 2020Biochemistry

An oligomeric state-dependent switch in FICD regulates AMPylation and deAMPylation of the chaperone BiP

L. A. Perera, C. Rato, Y. Yan, L. Neidhardt, S. H. McLaughlin, R. J. Read, S. Preissler, D. Ron

This paper identifies how FICD switches between AMPylation and deAMPylation of BiP by changing its oligomeric state, regulated by ATP/ADP levels.

bioRxiv · Apr 1, 2019Biochemistry