Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity
M. Kiss, L. Vande Walle, E. Lebegge, H. Van Damme, A. Murgaski, J. Qian, M. Ehling, S. Pretto, E. Bolli, J. Keirsse, Y. Elkrim, M. S. Martins, A. Fossoul, D. Lambrechts, M. Mazzone, , D. Laoui
This study shows IL-1β promotes tumor progression by mobilizing neutrophils to suppress antitumor immunity, independent of inflammasome and GSDMD.
bioRxiv · Aug 4, 2020Immunology