Author

D. Laoui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Lambrechts· 3 shared M. Kiss· 3 shared Y. Elkrim· 3 shared A. Debraekeleer· 2 shared A. Murgaski· 2 shared A. Smeets· 2 shared D. Kancheva· 2 shared E. Hadadi· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

D. Lambrechts

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Epigenomic programming of peripheral monocytes determines their transcriptional response to the tumor microenvironment

M. Kiss, L. Halasz, E. Hadadi, W. K. Berger, P. Tzerpos, S. Poliska, D. Kancheva, A. Debraekeleer, J. Brughmans, Y. Elkrim, L. Martens, Y. Saeys, B. Daniel, Z. Czimmerer, D. Laoui, , J. A. Van Ginderachter

This study shows that peripheral monocytes' epigenomic landscape is rewired by a distal tumor, shaping their transcriptional response upon tumor infiltration.

bioRxiv · Jun 19, 2024Immunology

Distinct cDC subsets co-operate in CD40 agonist response while suppressive microenvironments and lack of antigens subvert efficacy

A. Murgaski, M. Kiss, H. Van Damme, D. Kancheva, I. Vanmeerbeek, J. Keirsse, E. Hadadi, J. Brughmans, S. M. Arnouk, A. E. I. Hamouda, A. Debraekeleer, V. Bosteels, Y. Elkrim, L. Boon, S. Hoves, , D. Laoui

This study identifies cDC subsets that cooperate in CD40 agonist response and shows that suppressive microenvironments and antigen scarcity limit its efficacy in cancer.

bioRxiv · Dec 25, 2021 · PreprintCancer Biology

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop

Y. Hua, G. Vella, F. Rambow, E. Allen, A. A. Martinez, M. Duhamel, S. Junius, A. Smeets, D. Nittner, D. Laoui, S. Dimmeler, T. Hehlgans, A. Liston, G. Floris, D. Lambrechts, , G. Bergers

This paper shows that antiangiogenic immunotherapies convert postcapillary venules into high-endothelial venules that support TCF1+ T cell niches through a feed-forward loop involving CD8 and NK cells.

bioRxiv · Dec 24, 2021 · PreprintCancer Biology

Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity

M. Kiss, L. Vande Walle, E. Lebegge, H. Van Damme, A. Murgaski, J. Qian, M. Ehling, S. Pretto, E. Bolli, J. Keirsse, Y. Elkrim, M. S. Martins, A. Fossoul, D. Lambrechts, M. Mazzone, , D. Laoui

This study shows IL-1β promotes tumor progression by mobilizing neutrophils to suppress antitumor immunity, independent of inflammasome and GSDMD.

bioRxiv · Aug 4, 2020Immunology

A Pan-Cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling

J. Qian, S. Olbrecht, B. Boeckx, H. Vos, D. Laoui, E. Etlioglu, E. Wauters, V. Pomella, S. Verbandt, P. Busschaert, A. Bassez, A. Franken, M. Vanden Bempt, J. Xiong, B. Weynand, , D. Lambrechts

This study profiles single cells from multiple cancer types to create a pan-cancer blueprint of stromal cell heterogeneity, identifying shared and unique cell populations and their characteristics.

bioRxiv · Apr 1, 2020Cancer Biology