J. Qian

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

This study shows that Gγ13 signaling in tuft cells is essential for resolving lung inflammation and promoting recovery after severe injury.

Nociceptive neurons interact directly with gastric cancer cells via a CGRP/Ramp1 axis to promote tumor progression

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Force and the α-C-terminal domains bias RNApolymerase recycling

The paper investigates how force and α-C-terminal domains influence RNA polymerase recycling after termination, showing force biases diffusion direction and promoter recognition.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

Long noncoding RNAs emerge from transposon-derived antisense sequences and may contribute to infection stage-specific transposon regulation in a fungal phytopathogen

The paper identifies long noncoding RNAs (lncRNAs) in the fungal pathogen Blumeria hordei that are antisense to transposable elements and may regulate TE activity during infection.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.

Reciprocating RNA Polymerase batters throughroadblocks

This study investigates how RNA polymerase navigates protein roadblocks in E. coli, showing force-dependent effects and the role of GreA in facilitating passage.

Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

Spatiotemporal heterogeneity and the long-term impact of meteorological , environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

An interactive viral genome evolution network analysis system enabling rapid large-scale molecular tracing of SARS-CoV-2

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

This study identifies Prom1 and Notch as regulators of ciliary length and dynamics in multiciliated airway epithelial cells, contributing to mucociliary clearance and lung defense.

Fluorescence visualization of deep-buried hollow organs

This paper develops bright fluorophores and uses heavy water to improve fluorescence imaging of deep-buried hollow organs, achieving better visualization and diagnosis.

Simultaneous Optimization of Excitation Wavelength and Emission Window for Semiconducting Polymer Nanoparticles to Improve Imaging Quality

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

Self-confocal NIR-II fluorescence microscopy for in vivo imaging

This paper introduces self-confocal NIR-II fluorescence microscopy systems for in vivo imaging, improving adjustability and enabling cerebrovascular and hepatic imaging.

A thermodynamic model of bacterial transcription

This paper introduces a thermodynamic model of bacterial transcriptional pausing that predicts pause kinetics and factors like tension and GreA.

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth

The paper identifies a novel endothelial cell population in tumors that contributes to vascularization and growth.

AIE nanoparticles camouflaged with tumor cell-derived exosomes for NIR-II imaging-guided photothermal therapy

This paper develops hybrid nanovesicles combining tumor exosomes and AIE nanoparticles for enhanced NIR-II imaging and photothermal therapy of tumors.

Perfecting and extending the near-infrared biological window

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

Aggregation-induced emission dots assisted non-invasive fluorescence hysterography in near-infrared IIb window

This study uses AIE dots for non-invasive NIR-IIb fluorescence hysterography to visualize uterine structures and function in mice without impairing reproductive capacity.

Effects of Ca2+ on encystment and growth in Scrippsiella trochoidea

This study examines how varying calcium concentrations affect the growth and encystment of Scrippsiella trochoidea, finding increased cell density and cyst formation at lower calcium levels, with reductions at higher concentrations.

Identification of a new orthonairovirus associated with human febrile illness in China

This study identifies a new orthonairovirus, SGLV, associated with human febrile illness in northeastern China, showing its presence in ticks and clinical symptoms in infected patients.

Temperature and species-dependent regulation of browning in retrobulbar fat.

This study shows that retrobulbar fat in mice can be brown or white depending on temperature and species, with potential thermogenic function.

Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity

This study shows IL-1β promotes tumor progression by mobilizing neutrophils to suppress antitumor immunity, independent of inflammasome and GSDMD.

Protein enhanced NIR-IIb emission of indocyanine green for functional bioimaging

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

A Pan-Cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling

This study profiles single cells from multiple cancer types to create a pan-cancer blueprint of stromal cell heterogeneity, identifying shared and unique cell populations and their characteristics.

Forensic microbial system for high-resolution object provenance

This paper develops a synthetic microbial spore system for high-resolution object provenance tracking with rapid decoding and biocontainment.

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.