Th1/17 Cells Infiltrate Murine Cytomegalovirus-Infected Renal Allografts via Virus-Induced CCL20 and Promote Th1 Cells through IL-17A.
R. Dhital, S. Anand, Q. Zeng, V. M. Velazquez, S. R. Boddeda, J. Fitch, R. W. Minz, M. Minz, A. Sharma, R. Cianciolo, M. Shimamura
This study shows CMV infection increases Th17 cells in renal grafts via CCL20, which correlates with Th1 cells and reduces Tregs, and IL-17A inhibition lowers Th17 cells without affecting antiviral Th1 cells.
bioRxiv · Aug 5, 2021Immunology