R. Cianciolo

WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration

This study shows WHAMM is essential for kidney reabsorption and autophagosome membrane closure by polymerizing actin, with loss of WHAMM causing albuminuria and autophagy defects.

Th1/17 Cells Infiltrate Murine Cytomegalovirus-Infected Renal Allografts via Virus-Induced CCL20 and Promote Th1 Cells through IL-17A.

This study shows CMV infection increases Th17 cells in renal grafts via CCL20, which correlates with Th1 cells and reduces Tregs, and IL-17A inhibition lowers Th17 cells without affecting antiviral Th1 cells.