Cancer BiologybioRxiv
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
K. L. Hung, J. Luebeck, S. R. Dehkordi…·H. Y. Chang
This study introduces CRISPR-CATCH, a method to purify and analyze extrachromosomal DNA, revealing hypomethylation and structural details of ecDNA in cancer cells.
DOI 10.1038/s41588-022-01190-0