Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
K. Zhu, M. G. Jones, J. Luebeck, X. Bu, H. Yi, K. L. Hung, I. T.-L. Wong, S. Zhang, P. S. Mischel, H. Y. Chang, V. Bafna
CoRAL improves ecDNA structure reconstruction using long-read sequencing, outperforming short-read methods in simulations and cell-line datasets.
bioRxiv · Feb 15, 2024Cancer Biology
J. C. Rose, I. T.-L. Wang, B. Daniel, M. G. Jones, K. E. Yost, K. L. Hung, E. J. Curtis, P. S. Mischel, H. Chang
This study uses a CRISPR-based method to investigate ecDNA formation, showing efficient circularization and distinct repair pathways for ecDNA and chromosomal scars.
bioRxiv · Oct 22, 2023Cancer Biology
K. L. Hung, M. G. Jones, I. T.-L. Wong, J. T. Lange, J. Luebeck, E. Scanu, B. J. He, L. Brückner, R. Li, R. C. Gonzalez, R. Schmargon, J. R. Dörr, J. A. Belk, V. Bafna, B. Werner, , H. Y. Chang
This study shows that multiple extrachromosomal DNA species are coordinately inherited in cancer cells through mitotic co-segregation, enabling oncogene cooperation and guiding therapeutic strategies.
bioRxiv · Jul 18, 2023 · PreprintCancer Biology
K. L. Hung, J. Luebeck, S. R. Dehkordi, C. Coruh, J. A. Law, W. J. Greenleaf, P. S. Mischel, V. Bafna, H. Y. Chang
This study introduces CRISPR-CATCH, a method to purify and analyze extrachromosomal DNA, revealing hypomethylation and structural details of ecDNA in cancer cells.
bioRxiv · Nov 28, 2021Cancer Biology
J. T. Lange, C. Y. Chen, Y. Pichugin, F. Xie, J. Tang, K. L. Hung, K. E. Yost, Q. Shi, M. L. Erb, U. Rajkumar, S. Wu, C. Swanton, Z. Liu, W. Huang, H. Y. Chang, , P. S. Mischel
bioRxiv · Jun 11, 2021 · PreprintCancer Biology
K. L. Hung, K. E. Yost, L. Xie, S. Wu, J. T. Lange, C. V. Duffy, K. Kraft, J. Tang, Q. Shi, J. C. Rose, M. R. Corces, J. M. Granja, R. Li, U. Rajkumar, R. Tjian, , H. Y. Chang
The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.
bioRxiv · Nov 19, 2020Cancer Biology