MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?
H. H. K. Abbas, K. M. H. Alhamoudi, M. D. Evans, G. D. D. Jones, S. S. Foster
This study investigates MTH1's role in lung cancer cells, finding that its deficiency increases oxidative DNA damage but does not enhance cytotoxicity or response to standard therapies.
BMC Cancer · Apr 16, 2018Peer-reviewedCancer Biology