Cancer BiologybioRxiv
STUB1 is an intracellular checkpoint for interferon gamma sensing
S. Ng, S. Lim, A. C. N. Sim…·A. W. Partridge
This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.
DOI 10.1038/s41598-022-18404-4