Author

A. C. N. Sim

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Chandramohan· 1 shared A. Lau· 1 shared A. Loboda· 1 shared A. Schwaid· 1 shared A. W. Partridge· 1 shared A. Z. Fernandis· 1 shared B. Henry· 1 shared C. Li· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Chandramohan

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1 paper

Recent·Most cited

STUB1 is an intracellular checkpoint for interferon gamma sensing

S. Ng, S. Lim, A. C. N. Sim, R. Mangadu, A. Lau, C. Zhang, S. Bollinger Martinez, A. Chandramohan, U.-M. Lim, S. S. W. Ho, S. C. Chang, P. Gopal, L. Z. Hong, A. Schwaid, A. Z. Fernandis, , A. W. Partridge

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

bioRxiv · Dec 14, 2020Cancer Biology