Author

A. Chandramohan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

A. W. Partridge· 3 shared B. Henry· 3 shared C. J. Brown· 3 shared C. S. Verma· 3 shared C. W. Johannes· 3 shared H. Y. K. Kaan· 3 shared S. Kannan· 3 shared S. Ng· 3 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

A. W. Partridge

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

A. Chandramohan, H. Josien, T. Yuen, R. Duggal, D. Spiegelberg, L. Yan, Y. C. A. Juang, L. Ge, P. Aronica, H. Y. K. Kaan, Y. H. Lim, A. Peier, B. Sherborne, J. Hochman, S. Lin, , A. W. Partridge

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

bioRxiv · Feb 25, 2023 · PreprintBiochemistry

STUB1 is an intracellular checkpoint for interferon gamma sensing

S. Ng, S. Lim, A. C. N. Sim, R. Mangadu, A. Lau, C. Zhang, S. Bollinger Martinez, A. Chandramohan, U.-M. Lim, S. S. W. Ho, S. C. Chang, P. Gopal, L. Z. Hong, A. Schwaid, A. Z. Fernandis, , A. W. Partridge

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

bioRxiv · Dec 14, 2020Cancer Biology

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

S. Kannan, P. G. A. Aronica, S. Ng, D. Thean, Y. Frosi, S. Chee, J. Shimin, T. Y. Yuen, A. Sadruddin, H. Y. K. Kaan, A. Chandramohan, J. H. Wong, Y. S. Tan, F. J. Ferrer, P. Arumugam, , A. Partridge

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

bioRxiv · Sep 12, 2019 · PreprintBiochemistry

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

S. Ng, Y.-C. Juang, A. Chandramohan, H. Y. K. Kaan, A. Sadruddin, T. Y. Yuen, F. J. Ferrer, X. E. C. Lee, L. Xi, C. W. Johannes, C. J. Brown, S. Kannan, P. G. Aronica, N. Berglund, C. S. Verma, , D. P. Lane

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

bioRxiv · May 21, 2019Biochemistry

Novel Mechanism for Surface Layer Shedding and Regenerating in Bacteria Exposed to Metal-Contaminated Conditions

A. Chandramohan, E. Duprat, L. Remusat, S. Zirah, C. Lombard, A. Kish

The paper identifies a novel mechanism in bacteria where S-layers shed and regenerate in response to metal contamination, enhancing metal resistance.

bioRxiv · Oct 31, 2018Microbiology