p16High senescence restricts totipotent potential during somatic cell reprogramming
B. B. Grigorash, D. van Essen, L. Grosse, A. Emelyanov, B. Kanzler, C. Molina, E. Lopez, O. N. Demidov, C. Garrido, S. Saccani, D. Bulavin
This study shows that removing p16High senescent cells enhances 4F-induced reprogramming of somatic cells into totipotent-like stem cells by modulating NNMT and SAM levels.
bioRxiv · Aug 24, 2022 · PreprintCell Biology