C. Molina

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification

This study identifies impaired myofibroblast proliferation as a central feature of alveolar simplification in BPD using single-cell RNA sequencing and pharmacologic approaches.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

p16High senescence restricts totipotent potential during somatic cell reprogramming

This study shows that removing p16High senescent cells enhances 4F-induced reprogramming of somatic cells into totipotent-like stem cells by modulating NNMT and SAM levels.

A thermostable oral SARS-CoV-2 vaccine induces mucosal and protective immunity

This study develops a thermostable oral SARS-CoV-2 vaccine using e-VLPs that induces robust mucosal immunity and complete protection in animal models.

Instability of cooperation in finite populations

The paper shows that cooperation in evolutionary games is unstable in finite populations, contradicting infinite population assumptions.

Selection may oppose invasion, yet favour fixation: consequences for evolutionary stability

The paper shows that infinite-population models do not always predict evolutionary outcomes in finite populations, especially for small-effect mutations.