S. Sangadala

Local FK506 delivery induces osteogenesis in in vivo rat bone defect and rabbit spine fusion models

This study shows FK506 induces bone formation in human cells and two in vivo models, and can be used alone or with BMP-2 for spine disorders.

Sclerostin Small Molecule Inhibitors Promote Osteogenesis by Activating Canonical Wnt and BMP Pathways

This study identifies two small molecule inhibitors of sclerostin that enhance Wnt and BMP signaling, promoting bone formation in vitro and in vivo.