C. H. Kim

Sclerostin Small Molecule Inhibitors Promote Osteogenesis by Activating Canonical Wnt and BMP Pathways

This study identifies two small molecule inhibitors of sclerostin that enhance Wnt and BMP signaling, promoting bone formation in vitro and in vivo.

Serum albumin maintains Wnt water-solubility and activity

This study identifies serum albumin as a factor that maintains Wnt3a solubility and activity, enabling the development of serum-free Wnt3a preparations for therapeutic use.

Adolescent parvalbumin expression in the left orbitofrontal cortex shapes sociability in female mice

This study shows that adolescent social isolation in female mice leads to increased sociability, reduced parvalbumin expression, and decreased social sniffing activity in the left orbitofrontal cortex, highlighting the role of PV+ inhibitory circuits in shaping female social behavior.

Three Mutations Convert the Selectivity of a Protein Sensor From Nicotinic Agonists to S-Methadone For Use in Cells, Organelles, and Biofluids

The paper describes a fluorescent sensor that detects S-methadone with high selectivity and sensitivity in biological samples and cells.

Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands

The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.

Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

Expansion of the prime editing modality with Cas9 from Francisella novicida

This study expands prime editing by linking reverse transcriptase to FnCas9(H969A) nickase, enabling more precise and extended target gene modifications.

Simultaneous, cell-intrinsic downregulation of PD-1 and TIGIT enhances the effector function of CD19-targeting CAR T cells and promotes an early-memory phenotype

This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.

Heterogeneous transcriptome response to DNA damage at single cell resolution.

The paper shows that DNA damage induces heterogeneous transcriptome responses in cancer cells, with distinct transcriptional programs dictating cell fate outcomes such as checkpoint, apoptosis, or chemoresistance.

DeepIS: deep learning framework for three-dimensional label-free tracking of immunological synapses

This paper introduces a deep learning framework for 3D label-free tracking of immunological synapses using optical diffraction tomography and segmentation.