S. Schwarz

Peptide-stimulation of autologous T cells reverts immune checkpoint inhibitor resistance of hypermutated colorectal cancer cells

The paper shows that pre-stimulating T cells with tumor-specific peptides can overcome immune checkpoint inhibitor resistance in hypermutated colorectal cancer cells.

Kinases in motion: impact of protein and small molecule interactions on kinase conformations

This study uses KinCon-reporter technology to analyze conformational changes in disease-associated kinases upon drug, regulatory protein, and pathway activation interactions, revealing insights into therapeutic strategies.

Compensation to visual impairments and behavioral plasticity in navigating ants

This study shows that ants encode visual memories in a binocular, egocentric manner, and can compensate for visual impairment by re-learning routes with one eye, forming novel memories without erasing previous ones.

An intrinsic oscillator underlies visual navigation in ants.

This study shows that ants use an intrinsic oscillator for visual navigation, balancing exploration and exploitation through lateral oscillations and learned visual cues.

Aversive View Memory and Navigational Risk Sensitivity in the Desert Ant, Cataglyphis Velox

This study shows that desert ants use aversive visual memories to navigate, with hesitation behaviors linked to perceived risk and logarithmic duration perception.

A lateralised design for the interaction of visual memories and heading representations in navigating ants

This study combines behavioural experiments and computational modelling to show how ants use lateralised brain regions to integrate visual memories and heading representations for navigation.

Primate heart regeneration via migration and fibroblast repulsion by human heart progenitors

This study shows human heart progenitors can regenerate primate hearts by migrating to injury sites, repelling fibroblasts, and replacing damaged tissue through CXCL12/CXCR4 and SLIT2/ROBO1 signaling.

How do backward walking ants (Cataglyphis velox) cope with navigational uncertainty?

This study shows that backward walking ants use visual memories and other cues to navigate, despite uncertainty in their direction.

Avoiding pitfalls: Trace conditioning and rapid aversive learning during route navigation in desert ants

This study shows desert ants use aversive trace conditioning to learn route detours and avoid pit traps, with positive reinforcement shaping new routes.

Human-level recognition of blast cells in acute myeloid leukemia with convolutional neural networks

The paper trains a convolutional neural network to classify white blood cells with human-level accuracy, enabling efficient detection of blast cells in acute myeloid leukemia.