Author

T. Kaserer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

E. Stefan· 3 shared J. Fleischmann· 2 shared V. Kugler· 2 shared A. Dodaro· 1 shared A. Feichtner· 1 shared A. Heberle· 1 shared A. Lieb· 1 shared A. Sauerwein· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

E. Stefan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Kinases in motion: impact of protein and small molecule interactions on kinase conformations

V. Kugler, S. Schwaighofer, A. Feichtner, F. Enzler, J. Fleischmann, S. Strich, S. Schwarz, R. Wilson, P. Tschaikner, J. Troppmair, V. Sexl, P. Meier, T. Kaserer, E. Stefan

This study uses KinCon-reporter technology to analyze conformational changes in disease-associated kinases upon drug, regulatory protein, and pathway activation interactions, revealing insights into therapeutic strategies.

bioRxiv · Jan 11, 2024Biochemistry

A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system

F. Costacurta, A. Dodaro, D. Bante, H. Schoeppe, B. Sprenger, S. A. Moghadasi, J. Fleischmann, M. Pavan, D. Bassani, S. Menin, S. Rauch, L. Krismer, A. Sauerwein, A. Heberle, T. Rabensteiner, , E. Heilmann

This study identifies and characterizes SARS-CoV-2 Mpro mutations conferring resistance to nirmatrelvir using a VSV-based system and biochemical assays.

bioRxiv · Sep 22, 2023Microbiology

DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions

V. Kugler, A. Lieb, N. Guerin, B. R. Donald, E. Stefan, T. Kaserer

DISRUPTOR identifies oncogenic mutations disrupting protein interactions using an Osprey-based protocol, validated on clinically relevant mutations and confirmed experimentally.

bioRxiv · Nov 2, 2022 · PreprintCancer Biology