Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)
A. Chaikuad, S. E. Koschade, A. Stolz, K. Zivkovic, S. Shaid, C. Pohl, H. Ren, L. J. Lambert, N. D. P. Cosford, C. H. Brandts, S. Knapp
The paper presents the crystal structure of ULK2 with ATP inhibitors, identifies off-target effects of ULK1 inhibitors, and suggests structural insights for developing dual ULK1/2 inhibitors.
bioRxiv · Feb 14, 2019Biochemistry