Alk1 mutant endothelial cells undergo clonal expansion in mouse brain arteriovenous malformations
S. Shaligram, R. Zhang, W. Zhu, L. Ma, E. Winkler, M. Luo, Q. Li, T. Arnold, N. Santander, C. M. M. McDougall, J. Y. Wong, R. Liang, L. Barbosa Do Prado, C. Tang, H. Su
This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.
bioRxiv · May 20, 2020 · PreprintCell Biology