R. Liang

The HCoV-HKU1 N-terminal domain binds a wide range of 9-O-acetylated sialic acids presented on different glycan cores

Kilohertz volumetric imaging of in-vivo dynamics using squeezed light field microscopy

This paper introduces squeezed light field microscopy (SLIM), a method for high-speed 3D volumetric imaging, and demonstrates its application in tracking blood cell motion and neural activity in vivo.

Structural architecture of amyloid-β oligomers, curvilinear protofibrils and annular assemblies, imaged by cryo-EM and cryo-ET

The paper uses cryo-EM and cryo-ET to characterize the structural architecture of Aβ oligomers, curvilinear protofibrils, and annular assemblies, revealing their structural relationships and functional properties.

Distinct roles of the major binding residues in the cation-binding pocket of MelB

This study identifies the distinct roles of key residues in the cation-binding pocket of MelBSt through structural analysis, free energy simulations, and biochemical experiments.

Effects of point density on interpretability of lidar-derived forest structure metrics in two temperate forests

This study examines how lidar point density affects forest structure metrics in two temperate forests, finding site-specific thresholds and correlations that vary with density.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs

This paper describes the development of a more potent Lats kinase inhibitor, TDI-011536, which promotes cell proliferation and regeneration in mammalian tissues.

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

A chemical strategy toward novel brain-penetrant EZH2 inhibitors

This paper identifies a chemical strategy to develop brain-penetrant EZH2 inhibitors and reports two novel compounds with improved properties.

HIV proviral burden, genetic diversity and dynamics in viremic controllers who subsequently initiated suppressive antiretroviral therapy

This study characterizes proviral burden, diversity, and dynamics in viremic controllers before and after ART initiation using phylogenetic analysis and mathematical modeling.

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

3D-Visualization of Amyloid-β Oligomer and Fibril Interactions with Lipid Membranes by Cryo-Electron Tomography

This paper uses cryo-electron tomography to visualize how different Aβ assembly forms interact with lipid membranes, revealing that oligomers and protofibrils disrupt membrane integrity while monomers and fibrils have minimal impact.

Alk1 mutant endothelial cells undergo clonal expansion in mouse brain arteriovenous malformations

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

Life Inside A Dinosaur Bone: A Thriving Microbiome

This study shows that Late Cretaceous dinosaur bones host a living microbiome, distinct from surrounding sediment, challenging assumptions about fossil preservation and original organic material.

Molecular Mechanisms Governing Shade Responses in Maize

This study identifies molecular mechanisms of shade responses in maize by analyzing transcriptome changes and functionally testing a key transcription factor.