Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)
K. Watanabe, K. Morishita, X. Zhou, S. Shiizaki, Y. Uchiyama, M. Koike, I. Naguro, H. Ichijo
The paper identifies poly(ADP-ribose) as a regulator of ASK3 phase separation, enabling osmotic stress recognition and cell volume regulation.
bioRxiv · Apr 20, 2020Cell Biology