M. Koike

Importin α Characterizes a Micronuclear Environment Associated with Genomic Instability in Human Cancer Cells

The paper identifies importin α as a marker of a distinct micronuclear environment in cancer cells, associated with genomic instability and immune evasion.

Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation

This study shows that aromatase in adipose tissue protects bone in male mice by regulating phosphate reabsorption via NaPi2 proteins.

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

This study shows that loss of SPNS1 in the nervous system causes dysmyelination and white matter dysplasia in mice, suggesting a role for SPNS1 mutations in human congenital white matter disorders.

Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluidity

This study investigates how ALS/FTD-related p62 mutations affect liquid droplet properties, finding that some mutants show reduced Nrf2 activation and delayed turnover, while all exhibit slower inner fluidity.

Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)

The paper identifies poly(ADP-ribose) as a regulator of ASK3 phase separation, enabling osmotic stress recognition and cell volume regulation.

Autophagy controls lipid droplet formation by fine-tuning NCoR1 levels

This study shows autophagy regulates lipid droplet formation by modulating NCoR1 levels, affecting LXR target gene expression and lipid metabolism in the liver.

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis

This study shows peroxisomes regulate mitochondrial dynamics and apoptosis by affecting Drp1-mediated fission and caspase activation.

Acetylation of nuclear localization signal controls importin-mediated nuclear transport of Ku70

The paper shows acetylation of specific lysine residues in Ku70's NLS reduces its nuclear localization by impairing importin interaction.