Author

Y. Uchiyama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

H. Ichijo· 2 shared I. Naguro· 2 shared X. Zhou· 2 shared Y. Satou· 2 shared A. Ono· 1 shared A. Utsunomiya· 1 shared B. J. Y. Tan· 1 shared C. Ishii· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

H. Ichijo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

DNA damage response signaling to mitochondria drives senescence

S. Yamauchi, Y. Sugiura, J. Yamaguchi, X. Zhou, T. Odawara, S. Fukaya, I. Naguro, Y. Uchiyama, H. Ichijo

This study identifies BNIP3 as a mediator of DNA damage response signaling to mitochondria, which promotes senescence by altering mitochondrial structure and metabolism to increase p16 expression.

bioRxiv · Sep 22, 2022Cell Biology

Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis

B. J. Y. Tan, K. Sugata, O. Reda, M. Matsuo, K. Uchiyama, P. Miyazato, V. Hahaut, M. Yamagishi, K. Uchimaru, Y. Suzuki, T. Ueno, H. Suzushima, H. Katsuya, M. Tokunaga, Y. Uchiyama, , Y. Satou

This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.

bioRxiv · Sep 1, 2021 · PreprintMicrobiology

Movements of ancient human endogenous retroviruses detected in SOX2-expressing cells

K. Monde, Y. Satou, M. Goto, Y. Uchiyama, J. Ito, T. Kaitsuka, H. Terasawa, S. Yamaga, T. Matsusako, F. Y. Wei, I. Inoue, K. Tomizawa, A. Ono, T. Era, T. Sawa, Y. Maeda

The paper shows SOX2 regulates HERV-K transcription and retrotransposition in stem cells, suggesting a role in embryonic protection while limiting genomic harm.

bioRxiv · Jul 14, 2020Microbiology

Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)

K. Watanabe, K. Morishita, X. Zhou, S. Shiizaki, Y. Uchiyama, M. Koike, I. Naguro, H. Ichijo

The paper identifies poly(ADP-ribose) as a regulator of ASK3 phase separation, enabling osmotic stress recognition and cell volume regulation.

bioRxiv · Apr 20, 2020Cell Biology

Bacteroides uniformis enhances endurance exercise performance through gluconeogenesis

H. Morita, C. Kano, C. Ishii, N. Kagata, T. Ishikawa, Y. Uchiyama, S. Hara, T. Nakamura, S. Fukuda

This study shows that Bacteroides uniformis in the gut enhances endurance exercise performance by increasing gluconeogenesis through acetate and propionate production.

bioRxiv · Mar 4, 2020 · PreprintMicrobiology

Toxicokinetics of citreoviridin in vivo and in vitro.

Y. Uchiyama, M. Takino, M. Noguchi, N. Shiratori, Y. Sugita-Konishi

This study investigates the toxicokinetics of citreoviridin in swine and predicts human toxicokinetics by comparing in vitro and in vivo results, showing higher metabolism in humans.

Toxins · Jun 20, 2019Peer-reviewedPharmacology & Toxicology