Author

I. Naguro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

H. Ichijo· 6 shared H. Ryuno· 2 shared K. Morishita· 2 shared K. Watanabe· 2 shared X. Zhou· 2 shared Y. Uchiyama· 2 shared A. Herr· 1 shared H. Noma· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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6 shared papersCell Biology

H. Ichijo

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

ContactBlot: Microfluidic Control and Measurement of Cell-Cell Contact State to Assess Contact-Inhibited ERK Signaling

Y. Zhang, I. Naguro, H. Ryuno, A. Herr

The paper introduces ContactBlot, a microfluidic method to measure ERK signaling in HeLa cells under different contact states, finding reduced ERK activity in contact versus isolated cells.

bioRxiv · Nov 6, 2023Bioengineering

Pathophysiological Significance of Impaired KAT7-Dependent Histone H3K14 Acetylation During Zinc Deficiency

T. Fujisawa, S. Takenaka, L. Maekawa, T. Kowada, T. Matsui, S. Mizukami, Y. Kato, M. Suzuki, H. Noma, I. Naguro, H. Ichijo

The paper shows that zinc deficiency impairs KAT7-dependent H3K14ac at enhancers, upregulating ZIP10 and lipid droplet genes in mice, linking zinc homeostasis to epigenetic regulation.

bioRxiv · Oct 18, 2023Cell Biology

HES1 contributes to high salt stress response as an enhancer of NFAT5-DNA binding

H. Ryuno, Y. Hanafusa, I. Naguro, H. Ichijo

The paper identifies HES1 as a positive regulator of NFAT5-dependent transcription in response to high salt stress, enhancing osmoprotective gene expression and cytoprotection.

bioRxiv · Oct 10, 2022 · PreprintCell Biology

DNA damage response signaling to mitochondria drives senescence

S. Yamauchi, Y. Sugiura, J. Yamaguchi, X. Zhou, T. Odawara, S. Fukaya, I. Naguro, Y. Uchiyama, H. Ichijo

This study identifies BNIP3 as a mediator of DNA damage response signaling to mitochondria, which promotes senescence by altering mitochondrial structure and metabolism to increase p16 expression.

bioRxiv · Sep 22, 2022Cell Biology

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via PDH regulation

T. Ikizawa, K. Ikeda, M. Arita, S. Kitajima, T. Soga, H. Ichijo, I. Naguro

The paper shows hyperosmotic stress triggers rapid metabolic changes in cells through mitochondrial PDH regulation, maintaining ATP levels and survival.

bioRxiv · Jun 29, 2022 · PreprintCell Biology

Sodium ion regulates liquidity of biomolecular condensates in hyperosmotic stress response

K. Morishita, K. Watanabe, I. Naguro, H. Ichijo

This study shows that sodium ion influx regulates biomolecular condensate liquidity during hyperosmotic stress, with TRPM4 mediating Na+ entry and affecting condensate phase transitions.

bioRxiv · Jun 10, 2022 · PreprintCell Biology

Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)

K. Watanabe, K. Morishita, X. Zhou, S. Shiizaki, Y. Uchiyama, M. Koike, I. Naguro, H. Ichijo

The paper identifies poly(ADP-ribose) as a regulator of ASK3 phase separation, enabling osmotic stress recognition and cell volume regulation.

bioRxiv · Apr 20, 2020Cell Biology