Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2
A. Purificacao, S. Silva-Mendonca, L. Cruz, C. Sacramento, J. Temerozo, N. Fintelman-Rodrigues, C. Freitas, B. Godoi, M. Vaidergorn, J. Leite, L. Alvarez, M. Freitas, M. Silva, B. Martin, R. Lopez, , C. Nonato
This study identifies quinone-based compounds that inhibit HsDHODH and show anti-SARS-CoV-2 activity with low toxicity and nanomolar IC50.
bioRxiv · Oct 4, 2023Biochemistry