Author

C. Sacramento

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 1

Frequent Co-Authors

A. Ferreira· 2 shared A. Tanuri· 2 shared F. Bozza· 2 shared G. Barbosa-Lima· 2 shared M. Mattos· 2 shared P. Bozza· 2 shared P. Reis· 2 shared T. Souza· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

A. Ferreira

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

A. Purificacao, S. Silva-Mendonca, L. Cruz, C. Sacramento, J. Temerozo, N. Fintelman-Rodrigues, C. Freitas, B. Godoi, M. Vaidergorn, J. Leite, L. Alvarez, M. Freitas, M. Silva, B. Martin, R. Lopez, , C. Nonato

This study identifies quinone-based compounds that inhibit HsDHODH and show anti-SARS-CoV-2 activity with low toxicity and nanomolar IC50.

bioRxiv · Oct 4, 2023Biochemistry

Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

C. de Freitas, L. Higa, C. Sacramento, A. Ferreira, P. Reis, R. Delvecchio, F. Monteiro, G. Barbosa-Lima, Y. Vieira, M. Mattos, L. Hoelz, R. Leme, M. Bastos, F. Bozza, P. Bozza, , T. Souza

This study shows that sofosbuvir inhibits Yellow fever virus replication in vitro and protects mice from infection, suggesting it as a potential therapeutic option.

bioRxiv · Feb 15, 2018Microbiology

Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequela

A. Ferreira, C. Valle, P. Reis, G. Barbosa-Lima, Y. Vieira, M. Mattos, P. Silva, C. Sacramento, H. Neto, L. Campanati, A. Tanuri, K. Bruning, F. Bozza, P. Bozza, T. M. L. Souza

This study shows sofosbuvir reduces ZIKV levels and improves survival and long-term memory in infected mice.

bioRxiv · Apr 20, 2017Microbiology