B. Martin

The Pioneer Transcription Factor Oct4 Differentially Co-opts Bcl11a and Bcl11b to Regulate Reprogramming to Pluripotency

This study identifies how Oct4 differentially co-opts Bcl11a and Bcl11b to regulate reprogramming to pluripotency by revealing their opposing roles in cell fate conversion.

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

The effect of enriched versus inadequate housing conditions on eucalyptus smoke-induced cardiovascular dysfunction in mice

This study shows that enriched housing improves cardiopulmonary resilience to wildfire smoke in mice compared to depleted housing.

CZ CELLxGENE Discover: A single-cell data platform for scalable exploration, analysis and modeling of aggregated data

CZ CELLxGENE Discover provides a platform for scalable exploration and analysis of aggregated single-cell transcriptomic data across multiple studies.

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

This study identifies quinone-based compounds that inhibit HsDHODH and show anti-SARS-CoV-2 activity with low toxicity and nanomolar IC50.

Rosuvastatin-Eluting Gold Nanoparticle-Loaded Perivascular Implantable Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model

This study evaluates AuNP- and rosuvastatin-loaded perivascular wraps for reducing neointimal hyperplasia and improving AVF maturation in a chronic kidney disease rat model.

Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas

This study infuses gold nanoparticles into mesenchymal stem cell-seeded polymeric wraps to improve radiopacity for in vivo monitoring without affecting their beneficial effects on arteriovenous fistula maturation.

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

The paper uses machine learning to analyze human-chimpanzee variants in HARs, finding 43% affect chromatin state and 14% affect neurodevelopmental enhancer activity, with species-specific activity predicted by transcription factor footprints.

An inverse modelling study on the local volume changes during early growth of the fetal human brain

The paper uses MRI data and a nonlinear continuum mechanics model to infer the growth deformation gradient field of the fetal human brain, showing in-plane cortical expansion dominates early growth.

Precise genomic deletions using paired prime editing

This paper introduces PRIME-Del, a prime editing method for precise genomic deletions, showing higher precision than CRISPR/Cas9 and enabling deletions with non-PAM junctions.

High-throughput method to test antimicrobial gels against a multispecies oral biofilm

This paper introduces a high-throughput method using the Calgary Biofilm Device to test antimicrobial gels against multispecies oral biofilms and assess their efficacy.

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

This study uses macsGESTALT to trace metastatic cancer lineage and transcriptomes, revealing that late-hybrid EMT states drive metastasis and are linked to poor survival in human pancreatic cancer.

Skeletal muscle ceramides do not contribute to physical inactivity-induced insulin resistance

This study shows that skeletal muscle ceramides are not involved in physical inactivity-induced insulin resistance, and myriocin treatment improves glucose tolerance and insulin sensitivity.