Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT.
Y.-W. Zhang, S. Tavoulari, S. Sinning, A. Aleksandrova, L. R. Forrest, G. Rudnick
This study identifies conserved tyrosine residues and domain interactions in LeuT that enable substrate-induced conformational changes necessary for ion-substrate coupling in NSS transporters.
bioRxiv · Jul 6, 2018Biochemistry