Author

G. Rudnick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Y.-W. Zhang· 3 shared D. Boytsov· 2 shared L. R. Forrest· 2 shared A. Aleksandrova· 1 shared A. Basbaum· 1 shared A. Manglik· 1 shared A. Seth· 1 shared B. Bekele· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Y.-W. Zhang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of the potassium binding site in serotonin transporter SERT

E. Hellsberg, D. Boytsov, Q. Chen, M. Niello, M. Freissmuth, G. Rudnick, Y.-W. Zhang, W. Sandtner, L. R. Forrest

This study identifies the Na2 site as the potassium binding site in SERT using molecular dynamics simulations and site-directed mutagenesis.

Proceedings of the National Academy of Sciences · Apr 23, 2024Peer-reviewedBiochemistry

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

I. Singh, A. Seth, C. B. Billesbolle, J. Braz, R. M. Rodriguiz, K. Roy, B. Bekele, V. Craik, X.-P. Huang, D. Boytsov, P. Lak, H. R. O'Donnell, W. R. Sandtner, B. L. Roth, A. Basbaum, , G. Rudnick

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

bioRxiv · Jun 13, 2022Biochemistry

Chloride-dependent conformational changes in the GlyT1 glycine transporter

Y.-W. Zhang, S. Uchendu, V. Leone, R. T. Bradshaw, N. Sangwa, L. Forrest, G. Rudnick

This study investigates how chloride ions influence conformational changes in the GlyT1 glycine transporter by analyzing ligand binding and structural shifts in response to ions and substrates.

bioRxiv · Aug 20, 2020Biochemistry

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT.

Y.-W. Zhang, S. Tavoulari, S. Sinning, A. Aleksandrova, L. R. Forrest, G. Rudnick

This study identifies conserved tyrosine residues and domain interactions in LeuT that enable substrate-induced conformational changes necessary for ion-substrate coupling in NSS transporters.

bioRxiv · Jul 6, 2018Biochemistry