Author

Y.-W. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:mechanistic / dynamical model· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

G. Rudnick· 3 shared L. R. Forrest· 2 shared A. Aleksandrova· 1 shared D. Boytsov· 1 shared E. Hellsberg· 1 shared L. Forrest· 1 shared M. Freissmuth· 1 shared M. Niello· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

G. Rudnick

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3 papers

Recent·Most cited

Identification of the potassium binding site in serotonin transporter SERT

E. Hellsberg, D. Boytsov, Q. Chen, M. Niello, M. Freissmuth, G. Rudnick, Y.-W. Zhang, W. Sandtner, L. R. Forrest

This study identifies the Na2 site as the potassium binding site in SERT using molecular dynamics simulations and site-directed mutagenesis.

Proceedings of the National Academy of Sciences · Apr 23, 2024Peer-reviewedBiochemistry

Chloride-dependent conformational changes in the GlyT1 glycine transporter

Y.-W. Zhang, S. Uchendu, V. Leone, R. T. Bradshaw, N. Sangwa, L. Forrest, G. Rudnick

This study investigates how chloride ions influence conformational changes in the GlyT1 glycine transporter by analyzing ligand binding and structural shifts in response to ions and substrates.

bioRxiv · Aug 20, 2020Biochemistry

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT.

Y.-W. Zhang, S. Tavoulari, S. Sinning, A. Aleksandrova, L. R. Forrest, G. Rudnick

This study identifies conserved tyrosine residues and domain interactions in LeuT that enable substrate-induced conformational changes necessary for ion-substrate coupling in NSS transporters.

bioRxiv · Jul 6, 2018Biochemistry