Natural killer cell cytotoxicity shapes the clonal evolution of B cell leukaemia
M. C. Buri, M. R. Shoeb, A. Bykov, P. Repiscak, H. Baik, A. Dupanovic, F. O. David, B. Kovacic, F. Hall-Glenn, S. Dopa, J. Urbanus, L. Sippl, S. Stofner, D. Emminger, J. Cosgrove, , E. M. Putz
This study shows NK cells influence all phases of cancer immunoediting in B-ALL, promoting resistant clones through selective pressure and identifying LY6E as a marker of poor prognosis.
bioRxiv · Nov 16, 2023Cancer Biology