Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia
S. Okumura, U. Yokoyama, S. Oka, T. Sasaki, M. A. Cooley, Y. Hidaka, S. Tanifuji, M. Kaneko, T. Abe, R. M. Breyer, H. Homma, Y. Kato
This study identifies EP4 and fibulin-1 as key regulators of vascular intimal hyperplasia through VSMC proliferation, suggesting EP4 antagonists or fibulin-1 downregulation as potential therapeutic strategies.
bioRxiv · Nov 9, 2023Physiology