Y. Kato

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17

This study generates and characterizes monoclonal IgM and IgG antibodies against norovirus variants GII.4 and GII.17, revealing differences in binding mechanisms and affinity.

The Rubicon-WIPI axis regulates exosome biogenesis during aging

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.

Drinking-Water 4,4'-Methylenedianiline Establishes a Longitudinally Tractable Mouse Model of Cholestatic Liver Injury

This paper develops a drinking-water model of cholestatic liver injury in mice using MDA, showing sustained ALT elevation and distinct histological and biochemical features compared to TAA-DW.

Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia

This study identifies EP4 and fibulin-1 as key regulators of vascular intimal hyperplasia through VSMC proliferation, suggesting EP4 antagonists or fibulin-1 downregulation as potential therapeutic strategies.

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

Pathophysiological Significance of Impaired KAT7-Dependent Histone H3K14 Acetylation During Zinc Deficiency

The paper shows that zinc deficiency impairs KAT7-dependent H3K14ac at enhancers, upregulating ZIP10 and lipid droplet genes in mice, linking zinc homeostasis to epigenetic regulation.

A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives

This paper introduces a method to convert bacterial pathogens into live vaccines using unnatural amino acid-auxotrophic suicide derivatives, showing enhanced immunogenicity and safety.

Rechargeable Biomineral Induced by Sulfate Reducing Bacterium Cupidesulfovibrio sp. HK-II

This study investigates biogenic mackinawite produced by Cupidesulfovibrio sp. HK-II, showing it exhibits rechargeable properties through redox reactions and structural changes during discharge and recharge.

Single-cell transcriptome landscape of circulating CD4+ T cell populations in human autoimmune diseases

The paper identifies 12 transcriptional gene programs in CD4+ T cells from autoimmune diseases and shows their utility in disease characterization and prediction.

Characterization of Tryptophan Oxidation Affecting D1 Degradation by FtsH in the Photosystem II Quality Control of Chloroplasts

This study shows that Trp oxidation at the N-terminus of D1 protein enhances FtsH-mediated degradation during high-light stress in PSII repair.

In depth amino acid mutational analysis of the key interspecific incompatibility transmembrane factor Stigmatic Privacy 1

The paper identifies key amino acid residues in SPRI1 critical for its function in interspecific incompatibility in Arabidopsis thaliana.

The CWI pathway is activated through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae

This study shows high hydrostatic pressure activates the CWI pathway in yeast, leading to increased glycerol efflux via Fps1 to counteract osmotic stress.

A land plant specific VPS13 mediates polarized vesicle trafficking in germinating pollen

This study identifies AtVPS13a as a plant-specific protein required for directional vesicle trafficking during Arabidopsis pollen germination, linking it to pollen tube growth and cell wall deposition.

A highly contiguous genome assembly of red perilla (Perilla frutescens) domesticated in Japan

This paper presents a high-quality genome assembly of red perilla, identifying potential targets for genome editing to enhance metabolite production.

Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction

This study identifies remdesivir as a selective agonist of the urotensin-II receptor, linking its cardiotoxicity to receptor activation and genetic variants.

Identification of a novel chalcone reductase gene for isoliquiritigenin biosynthesis in dahlia (Dahlia variabilis)

This study identifies a novel chalcone reductase gene (DvCHR) in dahlia involved in isoliquiritigenin biosynthesis, showing evolutionary divergence from legume CHR genes.

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

A machine learning model that emulates experts decision making in vancomycin initial dose planning

This study develops a machine learning model to emulate expert decision-making for vancomycin initial dosing, achieving comparable therapeutic outcomes to expert-recommended regimens.

Clomipramine suppresses ACE2-mediated SARS-CoV-2 entry

This study shows clomipramine inhibits SARS-CoV-2 entry into cardiomyocytes and synergizes with remdesivir to suppress infection.

Disruption of Z-RNA-binding of ADAR1 induces Aicardi-Goutieres syndrome-like encephalopathy in mice

This study shows that disrupting ADAR1 p150's Z-RNA-binding domain in mice causes AGS-like encephalopathy with type I IFN signature, which is alleviated by MDA5 deletion.

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope tag insertion

The paper improves epitope tag insertion for 3D structure determination by using PA14 tags, which reduce structural changes in targets compared to PA12 tags.

Coordinate transcriptional and post-transcriptional repression of pro-differentiation genes maintains intestinal stem cell identity

This study identifies P-body dependent repression of pro-differentiation genes in Drosophila intestinal stem cells, maintaining their identity by preventing inappropriate translation and expression of differentiation genes.

PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade

This study identifies equine PD-1 and PD-L1 sequences, shows anti-bovine PD-L1 mAbs cross-react with equine PD-L1, and demonstrates PD-L1 blockade enhances Th1 cytokine production in equine immune cells.

A post-transcriptional program of chemoresistance by AU-rich elements and TTP

This study identifies a post-transcriptional mechanism of chemoresistance in leukemia involving AU-rich elements and TTP regulation.

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.