1-deoxysphingolipid biosynthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells
T. Cordes, R. S. Kuna, G. H. McGregor, S. V. Khare, J. Gengatharan, T. Muthusamy, C. M. Metallo
This study shows that 1-deoxysphingolipid synthesis, driven by SPT promiscuity, impairs anchorage-independent growth and plasma membrane endocytosis in cancer cells.
bioRxiv · Jan 19, 2022 · PreprintCancer Biology