C. M. Metallo

Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain

This study measures fatty acid composition in human milk and finds that monomethyl branched-chain fatty acids (mmBCFAs) vary with gestational weight gain, with lower levels in women with excess weight gain.

Non-targeted metabolomics identifies erythronate accumulation in cancer cells

The paper identifies erythronate accumulation in cancer cells using non-targeted metabolomics and suggests it may serve as a cancer biomarker.

Impaired BCAA catabolism during adipocyte differentiation decreases glycolytic flux

This study shows that impairing BCAA catabolism during adipocyte differentiation reduces glycolytic flux and alters metabolic pathways in adipocytes.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

1-deoxysphingolipid biosynthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells

This study shows that 1-deoxysphingolipid synthesis, driven by SPT promiscuity, impairs anchorage-independent growth and plasma membrane endocytosis in cancer cells.

Metabolic adaptation to progressive mitochondrial dysfunction in aging POLGD257A mice

This study examines metabolic changes in aging PolgD257A mice, revealing altered glycolysis, urea cycle dysfunction, and lipidome shifts linked to neuropathy.

NaCT (SLC13A5) facilitates citrate import and metabolism under nutrient-limited conditions

This study shows that NaCT-mediated citrate uptake supports cell survival under nutrient limitation and metal toxicity by enhancing metabolism and lipogenesis.

A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells

This paper develops a fluorescent probe to detect sphingosine in living cells and demonstrates its use in detecting sphingosine accumulation in NPC1 patient cells.

Microbiota control of maternal behavior regulates early postnatal growth of offspring

The paper identifies an E. coli strain that affects maternal behavior through microbiota-host interactions, leading to offspring growth stunting via impaired IGF-1 signaling.

Lipid availability influences the metabolic maturation of human pluripotent stem cell-derived cardiomyocytes

This study shows that lipid availability is critical for metabolic maturation of human pluripotent stem cell-derived cardiomyocytes, with exogenous lipid supplementation improving mitochondrial function and fatty acid oxidation.

Serine and glycine are essential for human muscle progenitor cell population expansion

This study identifies serine and glycine as essential for human muscle progenitor cell proliferation and shows their availability declines with age, impairing muscle regeneration.

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function

This study uses in vivo proteomics and nutrient tracing to show age-related metabolic changes in pancreatic β-cells improve glucose-stimulated insulin secretion.