A. Sahu

Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3-/- mice

The paper identifies retention of 129S genome in Nlrp3-/- mice causing NLRP1 hypersensitivity and transcriptional changes, and introduces a conditional Nlrp3 allele to resolve phenotypes.

Drug repurposing approach for potential Pfmrk inhibitors as antimalarial agents: an In-silico analysis

This paper identifies potential FDA-approved drugs as inhibitors of Pfmrk, a Plasmodium falciparum protein, using in silico methods.

Functional Relations of CSLD2, CSLD3, and CSLD5 Proteins during Cell Wall Synthesis in Arabidopsis

This study investigates the functional roles of CSLD2, CSLD3, and CSLD5 proteins in cell wall synthesis in Arabidopsis, showing their conserved {beta}-1,4 glucan synthase activities and distinct contributions to cell plate formation.

Dynamical modeling reveals RNA decay mediates the effect of matrix stiffness on aged muscle stem cell fate

This study shows that matrix stiffness affects aged muscle stem cell self-renewal through RNA decay dynamics, which can be modulated by young matrix environments.

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

Cardiac overexpression of microRNA-7 is associated with adverse cardiac remodeling

This study shows that cardiac overexpression of miRNA-7 leads to cardiac dilation instead of adaptive hypertrophy in response to stress, indicating adverse remodeling.

Insulin inhibits protein phosphatase 2A to impair β-adrenergic receptor function

This study shows insulin impairs β2AR function via GRK2 and PP2A inhibition, with PI3Kγ regulating PP2A to sustain β2AR phosphorylation.

The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function

This study uses a statistical physics approach to assess aging-related entropy in skeletal muscle and shows that Klotho overexpression improves muscle function in older mice but not beyond a certain age threshold.

Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

Non-axisymmetric shapes of biological membranes from locally induced curvature

This study shows that non-axisymmetric ridge-shaped membrane structures are energetically favorable under moderate to high resting tension, challenging the assumption of axisymmetry in membrane deformation.

Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of Mycobacterium tuberculosis

This paper reports the crystal structure of Rv0081, a transcription factor in M. tuberculosis, and identifies key residues involved in hypoxic gene regulation through biochemical analysis.

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.