Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus
T. Umeyama, Y. Hayashi, H. Shimosaka, T. Inukai, S. Yamagoe, S. Takatsuka, Y. Hoshino, M. Nagi, S. Nakamura, K. Kamei, K. Ogawa, Y. Miyazaki
This study uses CRISPR/Cas9 to demonstrate that the Cyp51A Gly138Ser SNP increases azole resistance in Aspergillus fumigatus by reducing susceptibility.
bioRxiv · May 1, 2018Microbiology