Y. Miyazaki

Stratification of viral shedding patterns in saliva of COVID-19 patients

This study stratifies SARS-CoV-2 viral shedding patterns in saliva into three groups with distinct durations using a mathematical model and clustering, but finds no clear clinical or miRNA biomarkers explaining the differences.

Improved Protein Model in SPICA Force Field

This paper improves the SPICA force field to better simulate proteins, including IDPs and peripheral proteins, by introducing secondary structure-dependent nonbonded parameters and re-optimizing interactions.

ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.

This study identifies ROR1 as a critical marker for pancreatic tumor-initiating cells with a partial EMT signature, showing its role in promoting tumor growth and relapse.

CiDRE+ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

This study identifies IL-10-driven M2c macrophages as key contributors to severe COVID-19 by facilitating SARS-CoV-2 infection and highlights CiDRE as a potential therapeutic target.

Hypoxic conditions promote Candida glabrata colonization in the intestinal tract and EPA6 plays a significant role in hypoxic adhesion to intestinal cells

This study shows hypoxia enhances Candida glabrata adhesion to intestinal cells, with EPA6 playing a key role in this process.

The SPICA Coarse-Grained Force Field for Proteins and Peptides

The paper develops and improves a coarse-grained force field for proteins and peptides, showing good performance in simulating membrane protein behavior and interactions.

C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

This study identifies a signaling pathway involving CNP, NPR2, PKG, BK channels, and TRPM7 that facilitates Ca2+ entry in growth plate chondrocytes to stimulate bone growth.

Ecosystem size and complexity dictate riverine biodiversity

This study shows ecosystem size and complexity equally influence riverine biodiversity across different regions.

Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus

This study uses CRISPR/Cas9 to demonstrate that the Cyp51A Gly138Ser SNP increases azole resistance in Aspergillus fumigatus by reducing susceptibility.