S. Nakamura

The Rubicon-WIPI axis regulates exosome biogenesis during aging

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.

The Role of Morphological Adaptability in Vibrio cholerae's Motility and Pathogenicity

This study examines how morphological changes in Vibrio cholerae affect its motility and pathogenicity in different viscosity environments.

Autophagosome development and chloroplast segmentation occur synchronously for piecemeal degradation of chloroplasts

The paper shows that autophagosome development and chloroplast segmentation occur together during chloroplast degradation in sugar-starved leaves.

Machine-learning-based motion tracking revealed the inverse correlation between adhesivity and surface motility of the leptospirosis spirochete

The paper uses machine learning to track motion of Leptospira interrogans without fluorescent labels, finding an inverse correlation between adhesion and motility.

Mechanism Underlying the Immune Responses of a Sublingual Vaccine for SARS-CoV-2 with RBD Antigen and Adjuvant, Poly(I:C) or AddaS03, in Non-human Primates

This study evaluates the safety and immune response of a sublingual SARS-CoV-2 vaccine with RBD antigen and Poly(I:C) or AddaS03 adjuvant in non-human primates, finding Poly(I:C) induces a balanced immune response.

Genistein enhances NAD+ biosynthesis by binding to Prohibitin 1 and upregulating nicotinamide phosphoribosyltransferase in adipocytes

This study shows genistein increases NAD+ biosynthesis in adipocytes by upregulating NAMPT through PHB1 binding and stabilization of CCAAT/enhancer-binding protein β.

Construction of Fosmid-based SARS-CoV-2 replicons for antiviral drug screening and replication analyses in biosafety level 2 facilities

This paper constructs SARS-CoV-2 replicons for antiviral drug screening in BSL-2 facilities and validates their replication and functionality.

Conserved cis-acting motifs and localization of transcripts and proteins of MFT2 in barley and rice

The paper examines the expression patterns and cis-acting regulatory elements of MFT2 homologs in barley and rice, showing conserved promoter motifs and scutellar expression.

Multiple genes evolved for fungal septal pore plugging identified via large-scale localization and functional screenings

The paper identifies 23 genes involved in fungal septal pore plugging through genomic comparisons, localization analysis, and functional screening.

Collective gradient sensing by dilute swimming bacteria without clustering

This study shows that dilute swimming bacteria enhance taxis through collective migration without clustering, by suppressing orientation fluctuations and preventing population dispersion.

SARS-CoV-2 Sublingual Vaccine with RBD Antigen and Poly(I:C) Adjuvant: Preclinical Study in Cynomolgus Macaques

This study evaluates a sublingual SARS-CoV-2 vaccine with RBD antigen and poly(I:C) adjuvant in cynomolgus macaques, showing mucosal and systemic immune responses without allergic reactions.

Novel monoclonal antibodies showing broad neutralizing activity for SARS-CoV-2 variants including Omicrons BA.5 and BA.2.75

Genetic and lipidomic identification of tuberculostearic acid as a controller of mycobacterial membrane compartmentalization

The paper identifies tuberculostearic acid (TBSA) as a key lipid controlled by the gene cfa, which regulates membrane compartmentalization in Mycobacterium smegmatis.

No circadian clock-gene circuit in the generation of cellular bioluminescence rhythm of CaMV35S::PtRLUC in duckweed

The paper shows that the CaMV35S::PtRLUC bioluminescence rhythm in duckweed is not controlled by the circadian clock gene circuit, unlike the AtCCA1::LUC+ rhythm.

Oxytocin and Emotional Tear in Dogs

This study investigates the relationship between emotional arousal, tear volume, and oxytocin in dogs, finding that oxytocin increases tear volume during emotional reunions with owners.

The oxytocin system regulates tearing

This study identifies the role of the oxytocin system in regulating tear production by linking hypothalamic oxytocin neurons to the superior salivatory nucleus.

Molecular mechanisms of Plasmodium development in male and female Anopheles mosquitoes

This study compares the vector competence of male and female Anopheles mosquitoes for Plasmodium parasites, finding higher oocyst production in males and variable gene expression in response to infection.

Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant

This paper shows engineered ACE2 neutralizes Omicron and other sarbecoviruses effectively despite its high number of spike mutations.

Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells

This study shows that anti-nucleolin aptamers iSN04 and AS1411 inhibit the growth of embryonal rhabdomyosarcoma cells by targeting nucleolin expression.

Enterococcus spp. have higher fitness for survival, in a pH-dependent manner, in pancreatic juice among duodenal bacterial flora

The paper investigates the survival of Enterococcus faecalis in pancreatic juice under different pH conditions and finds it has higher fitness in alkaline environments.

Light-dependent synthesis of a nucleotide second messenger controls bacterial motility

The paper shows light-dependent cAMP synthesis controls bacterial motility via a novel photoresponsive enzyme in a soil bacterium.

Adaptive diversification in the cellular circadian behavior of Arabidopsis leaf- and root-derived cells

This study shows that leaf- and root-derived cells of Arabidopsis have distinct circadian properties, with leaf cells showing stronger persistence against environmental fluctuations.

Identification, crystallization and epitope determination of public TCR shared and expanded in COVID-19 patients

The paper identifies and crystallizes public TCRs from SARS-CoV-2-specific Tfh cells in COVID-19 patients, showing they recognize conserved spike epitopes and cross-react with symbiotic bacteria.

Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus

This study shows that myogenetic oligodeoxynucleotides (myoDNs) can restore myoblast differentiation in diabetes mellitus patients by reducing myostatin and interleukin-8.

Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin

The paper identifies bacterial-derived oligodeoxynucleotides (myoDNs) that promote skeletal muscle myoblast differentiation by targeting nucleolin.

High affinity modified ACE2 receptors protect from SARS-CoV-2 infection in hamsters

The paper engineers high-affinity ACE2 receptors to neutralize SARS-CoV-2 in hamsters, showing protection against infection without viral escape mutations.

Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution

This study experimentally demonstrates coevolution between host and parasitic RNA molecules, showing how parasitic replicators drive genetic diversity in prebiotic evolution.

Implications of back-and-forth motion and powerful propulsion for spirochetal invasion

This study investigates the motility of Leptospira spp. by analyzing their movement in a liquid-gel interface and measuring their propulsion force and efficiency.

Cooperative stator assembly of bacterial flagellar motor mediated by rotation

The paper shows that stator units in bacterial flagellar motors bind cooperatively, with rotation enhancing binding and triggering a chain reaction of stator assembly.

Insight into motility-dependent pathogenicity of the zoonotic spirochete Leptospira

The paper investigates how motility and adhesivity of Leptospira spp. relate to their pathogenicity by analyzing their movement on host tissues.