Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing
F. Iglesias, S. Weston, S. V. Avila, H. Zhou, S. Yousef, M. Fluchel, E. Morales, M. L. Olson, S. V. Radhakrishnan, T. Luetkens
This study develops synNotch T cells that deliver IFN-gamma to neuroblastoma cells, restoring HLA expression and enhancing T cell-mediated killing without increasing immune checkpoints or systemic IFN-gamma.
bioRxiv · Jun 21, 2022 · PreprintBioengineering