S. Weston

The most remarkable migrants - systematic analysis of the Western European insect flyway at a Pyrenean mountain pass

The paper systematically monitors insect migration at a Pyrenean mountain pass, finding a large annual insect flow influenced by environmental factors and estimating a significant bioflow across the mountain range.

SIRT-1 is required for release of enveloped picornaviruses

This study shows SIRT-1 is essential for EV-D68 infection and enveloped virus release, independent of its deacetylase activity or autophagy.

Migratory hoverflies orientate north during spring migration

The paper provides ground confirmation that spring migratory hoverflies have an innate northward orientation, observed during their arrival in the UK.

Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing

This study develops synNotch T cells that deliver IFN-gamma to neuroblastoma cells, restoring HLA expression and enhancing T cell-mediated killing without increasing immune checkpoints or systemic IFN-gamma.

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells

This study uses proteomic analysis of GSK3β knockout colorectal cancer cells to identify altered cell adhesion and metabolic pathways.

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

This study evaluates the in vitro antiviral activity of three Ebola and Marburg virus inhibitors against SARS-CoV-2 and explores their potential mechanisms of action.

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo

This study evaluates 20 FDA-approved drugs for antiviral activity against SARS-CoV-2 and SARS-CoV, finding 17 inhibit SARS-CoV-2 at non-cytotoxic concentrations and two protect mice from SARS-CoV disease.

Comparative analysis reveals adaptive evolution of bat IFITMs and a novel antiviral determinant

The paper identifies adaptive evolution in bat IFITMs and a novel antiviral determinant involving S-palmitoylation at codon 70 and cysteine residues.