Across functional boundaries: making non-neutralizing antibodies to neutralize HIV-1 and mediate Fc-mediated effector killing of infected cells
J. Richard, D. Nguyen, W. D. Tolbert, R. Gasser, s. ding, D. Vezina, S. Yu Gong, J. Prevost, G. Gendron-Lepage, H. Medjahed, S. Gottumukkala, A. Finzi, M. Pazgier
This paper designs Ab-CD4 chimeric proteins that open HIV-1 Env trimers to expose non-neutralizing epitopes, enabling both neutralization and ADCC against HIV-1.
bioRxiv · Aug 13, 2021Immunology