Author

D. Vezina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Assay:proteomics· 8 Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Research Focus:clustering· 2

Frequent Co-Authors

A. Finzi· 10 shared J. Richard· 9 shared G. Goyette· 8 shared J. Prevost· 8 shared S. Y. Gong· 8 shared R. Gasser· 7 shared A. Tauzin· 6 shared G. Beaudoin-Bussieres· 6 shared

Activity by Year

2021-2022 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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10 shared papersMicrobiology

A. Finzi

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

Y. Chen, J. Prevost, I. Ullah, H. Romero, V. Lisi, W. D. Tolbert, J. R. Grover, S. Ding, S. Y. Gong, G. Beaudoin-Bussieres, R. Gasser, M. Benlarbi, D. Vezina, S. P. Anand, D. Chatterjee, , A. Finzi

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

bioRxiv · Jul 27, 2022 · PreprintMicrobiology

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

S. Ding, S. Y. Gong, J. Grover, M. Mohammadjavad, Y. Chen, D. Vezina, G. Beaudoin-Bussieres, V. T. Verma, G. Goyette, J. Richard, D. Yang, A. B. Smith, M. Pazgier, M. Cote, C. Abrams, , C. Baron

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

bioRxiv · Feb 3, 2022Microbiology

SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses

D. Chatterjee, A. Tauzin, L. Marchitto, S. Y. Gong, M. Boutin, C. Bourassa, G. Beaudoin-Bussieres, Y. Bo, S. Ding, A. Laumaea, D. Vezina, J. Perreault, L. Gokool, C. Morrisseau, P. Arlotto, , A. Finzi

This study evaluates how plasma from individuals with a 16-week interval between BNT162b2 mRNA vaccine doses recognizes and neutralizes the Omicron Spike compared to other variants.

bioRxiv · Dec 21, 2021Microbiology

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

M. Nayrac, M. Dube, G. Sannier, A. Nicolas, L. Marchitto, O. Tastet, A. Tauzin, N. Brassard, G. Beaudoin-Bussieres, D. Vezina, S. Y. Gong, M. Benlarbi, R. Gasser, A. Laumaea, C. Bourassa, , D. E. Kaufmann

The paper examines B and T cell immunity responses to a 16-week interval BNT162b2 vaccine regimen, finding robust immune memory and functional associations between immune components.

bioRxiv · Dec 18, 2021Immunology

HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC mediated by plasma from infected individuals

J. Prevost, H. Medjahed, D. Vezina, H.-C. Chen, B. H. Hahn, A. B. Smith, A. Finzi

This study shows that HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC by reducing the exposure of uncleaved Env to non-neutralizing antibodies.

bioRxiv · Oct 26, 2021Microbiology

An anti-SARS-CoV-2 non-neutralizing antibody with Fc-effector function defines a new NTD epitope and delays neuroinvasion and death in K18-hACE2 mice

G. Beaudoin-Bussieres, Y. Chen, I. Ullah, J. Prevost, W. D. Tolbert, K. Symmes, S. Ding, M. Benlarbi, S. Y. Gong, A. Tauzin, R. Gasser, D. Chatterjee, D. Vezina, G. Goyette, J. Richard, , A. Finzi

bioRxiv · Sep 8, 2021 · PreprintMicrobiology

Across functional boundaries: making non-neutralizing antibodies to neutralize HIV-1 and mediate Fc-mediated effector killing of infected cells

J. Richard, D. Nguyen, W. D. Tolbert, R. Gasser, s. ding, D. Vezina, S. Yu Gong, J. Prevost, G. Gendron-Lepage, H. Medjahed, S. Gottumukkala, A. Finzi, M. Pazgier

This paper designs Ab-CD4 chimeric proteins that open HIV-1 Env trimers to expose non-neutralizing epitopes, enabling both neutralization and ADCC against HIV-1.

bioRxiv · Aug 13, 2021Immunology

Contribution of single mutations to selected SARS-CoV-2 emerging variants Spike antigenicity

S. Y. Gong, D. Chatterjee, J. Richard, J. Prevost, A. Tauzin, R. Gasser, Y. Bo, D. Vezina, G. Goyette, G. Gendron-Lepage, H. Medjahed, M. Roger, M. Cote, A. Finzi

The paper evaluates how single mutations in SARS-CoV-2 Spike protein affect antigenicity and ACE2 binding in emerging variants.

bioRxiv · Aug 4, 2021Microbiology

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

W. Mothes, W. Li, Y. Chen, J. Prevost, I. Ullah, M. Lu, S. Y. Gong, A. Tauzin, R. Gasser, D. Vezina, S. P. Anand, G. Goyette, D. Chaterjee, S. Ding, W. D. Tolbert, , A. Finzi

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

bioRxiv · Aug 2, 2021Microbiology

A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses

A. Tauzin, M. Nayrac, M. Benlarbi, S. Y. Gong, R. Gasser, G. Beaudoin-Bussieres, N. Brassard, A. Laumaea, D. Vezina, J. Prevost, S. P. Anand, C. Bourassa, G. Gendron-Lepage, H. Medjahed, G. Goyette, , A. Finzi

This study shows a single dose of the BNT162b2 mRNA vaccine elicits strong antibody and T cell responses, including Fc-mediated effector functions, and boosts pre-existing immunity in previously infected individuals.

bioRxiv · Mar 18, 2021 · PreprintImmunology