S. Z. Chou

Cryo-EM structure of the bacterial effector protein SipA bound to F-actin reveals a unique mechanism for filament stabilization

The paper reports the cryo-EM structure of SipA bound to F-actin, revealing how it stabilizes actin filaments and shows this activity is separate from its role in inflammation.

Cryo-EM structures of both ends of the actin filament explain why the barbed end elongates faster than the pointed end

The paper uses cryo-EM to determine the structures of actin filament ends, explaining why barbed ends elongate faster than pointed ends and why pointed ends dissociate phosphate more rapidly.

Cryo-electron microscopy structures of pyrene-labeled ADP-Pi- and ADP-actin filaments

The paper reports cryo-EM structures of pyrene-labeled actin filaments with ADP and ADP-phosphate, explaining fluorescence changes during polymerization and interactions with myosin, cofilin, and profilin.

Structural basis for polarized elongation of actin filaments

This study uses molecular dynamics simulations to explain the structural basis for the asymmetric polymerization rates of actin filament ends.

Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides

The paper determines cryo-EM structures of actin filaments with different bound nucleotides, revealing how polymerization affects ATP hydrolysis and filament growth.

Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA and actin filaments

The paper investigates how ATP, WASp-VCA, and actin filaments induce conformational changes in the Arp2/3 complex using FRET and electron microscopy.