Author

M. Lara-Tejero

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:cryo-EM· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J. E. Galan· 5 shared J. Liu· 2 shared W. Li· 2 shared B. Hu· 1 shared C. Butan· 1 shared C. Fowler· 1 shared D. Park· 1 shared E. Guo· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersMicrobiology

J. E. Galan

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6 papers

Recent·Most cited

Cryo-EM structure of the bacterial effector protein SipA bound to F-actin reveals a unique mechanism for filament stabilization

E. Guo, S. Z. Chou, M. Lara-Tejero, J. E. Galan

The paper reports the cryo-EM structure of SipA bound to F-actin, revealing how it stabilizes actin filaments and shows this activity is separate from its role in inflammation.

bioRxiv · Dec 21, 2023 · PreprintMicrobiology

Assembly and architecture of the type III secretion sorting platform

J. E. Soto, J. E. Galan, M. Lara-Tejero

This study maps the assembly of the type III secretion sorting platform using structure modeling and in vivo crosslinking, revealing inter-subunit interactions and the genetic basis of its formation.

bioRxiv · Sep 23, 2022Microbiology

Typhoid toxin sorting and exocytic transport from Salmonella Typhi infected cells

S.-J. Chang, Y.-Y. Lin, M. Lara-Tejero, J. E. Galan

This study identifies the cellular machinery and receptor involved in the exocytic transport of typhoid toxin from Salmonella Typhi-infected cells.

bioRxiv · Aug 10, 2021Microbiology

High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway

C. Butan, M. Lara-Tejero, W. Li, J. Liu, J. Galan

The paper presents a high-resolution structure of the Salmonella type III secretion export apparatus in situ, revealing membrane remodeling and a secretion pathway.

bioRxiv · Jul 21, 2019Microbiology

Alternate subunit assembly diversifies the function of a bacterial toxin

J. E. Galan, C. Fowler, G. Stack, X. Xiao, M. Lara-Tejero

This study shows that Salmonella Typhi produces two distinct typhoid toxin variants with different delivery components but shared active subunits, leading to functional versatility.

bioRxiv · Apr 30, 2019Microbiology

Visualization of the type III secretion mediated Salmonella-host cell interface using cryo-electron tomography

J. Liu, D. Park, M. Lara-Tejero, J. E. Galan, W. Li, M. N. Waxham, B. Hu

This study uses cryo-electron tomography to visualize the Salmonella-host cell interface mediated by the type III secretion system, revealing the translocon's structure and its role in effector translocation.

bioRxiv · Jun 29, 2018Microbiology