Author

J. E. Galan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Lara-Tejero· 5 shared B. Hu· 1 shared C. Fowler· 1 shared D. Park· 1 shared E. Guo· 1 shared G. Stack· 1 shared J. E. Soto· 1 shared J. Liu· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersMicrobiology

M. Lara-Tejero

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Author profile →

6 papers

Recent·Most cited

Loss of function of metabolic traits in typhoidal Salmonella without apparent genome degradation

L. F. M. Machado, J. E. Galan

This study identifies single amino acid substitutions in S. Typhi that inactivate metabolic pathways, explaining its metabolic limitations compared to S. Paratyphi A.

bioRxiv · Feb 14, 2024 · PreprintMicrobiology

Cryo-EM structure of the bacterial effector protein SipA bound to F-actin reveals a unique mechanism for filament stabilization

E. Guo, S. Z. Chou, M. Lara-Tejero, J. E. Galan

The paper reports the cryo-EM structure of SipA bound to F-actin, revealing how it stabilizes actin filaments and shows this activity is separate from its role in inflammation.

bioRxiv · Dec 21, 2023 · PreprintMicrobiology

Assembly and architecture of the type III secretion sorting platform

J. E. Soto, J. E. Galan, M. Lara-Tejero

This study maps the assembly of the type III secretion sorting platform using structure modeling and in vivo crosslinking, revealing inter-subunit interactions and the genetic basis of its formation.

bioRxiv · Sep 23, 2022Microbiology

Typhoid toxin sorting and exocytic transport from Salmonella Typhi infected cells

S.-J. Chang, Y.-Y. Lin, M. Lara-Tejero, J. E. Galan

This study identifies the cellular machinery and receptor involved in the exocytic transport of typhoid toxin from Salmonella Typhi-infected cells.

bioRxiv · Aug 10, 2021Microbiology

Alternate subunit assembly diversifies the function of a bacterial toxin

J. E. Galan, C. Fowler, G. Stack, X. Xiao, M. Lara-Tejero

This study shows that Salmonella Typhi produces two distinct typhoid toxin variants with different delivery components but shared active subunits, leading to functional versatility.

bioRxiv · Apr 30, 2019Microbiology

Visualization of the type III secretion mediated Salmonella-host cell interface using cryo-electron tomography

J. Liu, D. Park, M. Lara-Tejero, J. E. Galan, W. Li, M. N. Waxham, B. Hu

This study uses cryo-electron tomography to visualize the Salmonella-host cell interface mediated by the type III secretion system, revealing the translocon's structure and its role in effector translocation.

bioRxiv · Jun 29, 2018Microbiology